Arion Chatziioannou, Ph.D.
Magnus Dahlbom, Ph.D.

Research Interests:

My research interests lie at the interface of physics and biology and are focused on developing methodologies for the non-invasive monitoring of cancer growth and therapy. My doctoral research efforts at McMaster University, Canada were aimed at developing both experimental and theoretical methods for the depth-resolved optical monitoring of light-sensitive anti-cancer agent pharmacokinetics in superficial tissues. My postdoctoral research time at Massachusetts General Hospital / Harvard Medical School was invested in developing quantitative intravital microscopy methodologies for the analysis of barriers to drug delivery in tumor-bearing mice. I am now very excited to be at UCLA where I have the opportunity to be trained in both small animal and clinical multi-modality imaging. My present efforts in Prof. Arion Chatziioannou's lab are focused on computational feasibility studies of bioluminescence tomography, as part of developing a combined optical/PET mouse imaging system. In addition, I am profiting from the strong PET tradition at UCLA by pursuing some PET/CT clinical training under the guidance of Prof. Magnus Dahlbom.

Assistant Professor
University of Texas at Arlington
Bioengineering Department

Alexandrakis G, Rannou FR and Chatziioannou AF. 3D bioluminescence imaging by use of a combined optical-PET tomographic system: A computer simulation feasibility study. (Manuscript under preparation).

Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, and Jain RK. Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors. Nature Med. 10, 203-207 (2004).

Alexandrakis G, Busch DR, Faris GW, and Patterson MS. Determination of the optical properties of two-layer turbid media by use of a frequency domain hybrid Monte Carlo diffusion model. Appl. Opt. 40, 3810-3821 (2001).

Alexandrakis G, Farrell TJ, and Patterson MS. Monte Carlo - diffusion hybrid model for photon migration in a two-layer turbid medium in the frequency domain. Appl. Opt. 39, 2235-2244 (2000).

Alexandrakis G, Farrell TJ, and Patterson MS. Accuracy of the diffusion approximation in determining the optical properties of a two-layer turbid medium. Appl. Opt. 37, 7401-7410 (1998).