Our research interests center around understanding and using molecular recognition (protein-protein, nucleic acid-nucleic acid, and protein-nucleic acid) to distinguish tumor cells from normal cells and to develop practical applcations in oncology - diagnostic or therapeutic. Recent work has focused on genetic engineering of antibodies to provide optimal agents for delivery of radionuclides to tumor cells. Monoclonal antibodies specific for human tumor antigens have been re-engineered to reduce immunogenicity (by chimerization or humanization), and engineered fragments with improved pharmacokinetic properties have been produced. Biological therapies based on engineered antibodies are also under investigation, including retargeting T-cells using antibody-T cell receptor fusion proteins, and intracellular expression of single-chain antibodies.

New biological probes for imaging are being developed. Antibodies, peptides, and oligonucleotides tagged with positron-emitting isotopes can provide highly specific tools for examining gene expression and function in cells and tissues, and ultimately, patients.